It acts by the decrease in oxygen radicals, increase in blood flow and production of protective prostaglandins in ulcer mucosa, which accelerates the process of healing. Further studies are needed to clarify these possible advantages of rebamipide. They concluded that, rebamipide is an effective and safe drug in the treatment of recurrent oral ulcers. It is metabolized in the liver by human cytochrome P enzyme.
Side-effects of rebamipide Adverse drug reactions to rebamipide is not common, side effects seen are mild and can be corrected with dose adjustment. Drug interactions of rebmipide with other drugs is very low and safely used concomitantly with other drugs. In addition, it protects the gastric mucosa against acute injury caused by various noxious and ulcerogenic factors.
Till now, there are no randomized, placebo-controlled studies of rebamipide in the treatment of recurrent oral aphthae. Moreover, rebamipide may enhance eradication of H.
Speech is painful and all these put-together cause depression in the individual.
Dosage The adult dosage of rebamipide is mg orally three times daily. Pregnancy and lactation It is a category C drug. Lactation should be avoided when rebamipide is administered. The inhibition of immunoinflammatory responses by rebamipide in H. The treatment modalities tried for recurrent aphthae are vitamins, antivirals, thalidomide, colchicine, topical and oral steroids, etc.
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